Monograph Details
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Dermatological Disorders
> Acne
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SOLODYN |
| Manufacturer |
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Medicis Pharmaceuticals Corp |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Tetracycline antibiotic. |
| Generic Name |
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Minocycline (as HCl) 45mg, 90mg, 135mg; ext-rel tabs. |
| Indications |
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Inflammatory lesions of non-nodular moderate to severe acne. |
| Children |
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Not recommended. |
| Adults |
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Swallow whole. Give once daily for up to 12 weeks. Dose based on weight: approximately 1mg/kg. 45–59kg: 45mg. 60–90kg: 90mg. 91–136kg: 135mg. Renal impairment: reduce dose or extend dosing intervals. |
| Precautions |
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Not interchangeable with other minocycline products. Renal or hepatic impairment. Monitor blood, renal, or hepatic function. Pregnancy (Cat.D), nursing mothers: not recommended. |
| Interactions |
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Antacids, iron, zinc, calcium, magnesium, urinary alkalinizers reduce absorption. Avoid penicillins, methoxyflurane, isotretinoin. Monitor PT with oral anticoagulants. May antagonize oral contraceptives. |
| Adverse Reactions |
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Headache, fatigue, dizziness, GI upset, rash, increased BUN, hepatotoxicity, tinnitus, tooth discoloration, pseudotumor cerebri, photosensitivity, hyperpigmentation, autoimmune syndromes. |
| How Supplied |
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Tabs—30, 90, 100 |
| Additional Resources |
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• Related Prescribing Note |
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