Monograph Details
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Dermatological Disorders
> Acne
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MONODOX |
| Manufacturer |
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Oclassen Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Tetracycline antibiotic. |
| Generic Name |
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Doxycycline monohydrate 50mg, 100mg; caps. |
| Indications |
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Adjunct in severe acne. |
| Children |
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Not applicable. |
| Adults |
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200mg in 2–4 divided doses for 1 day, then 100mg/day in 1–2 doses. Reduce dose after improvement. Take with fluid. |
| Precautions |
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Monitor blood, renal, and hepatic function in long-term use. Sunlight or UV light. Pregnancy (Cat.D), nursing mothers: not recommended. |
| Interactions |
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May increase digoxin levels. Antacids, iron, zinc, calcium, magnesium reduce absorption. Avoid penicillins, methoxyflurane. Carbamazepine, hydantoins, barbiturates may decrease effectiveness. Monitor prothrombin time with oral anticoagulants. Oral contraceptives may be less effective. |
| Adverse Reactions |
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Photosensitivity, GI upset, rash, blood dyscrasias, hepatotoxicity. |
| How Supplied |
Caps 50mg—100
100mg—50, 250 |
| Additional Resources |
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• Related Prescribing Note |
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