Monograph Details
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Central Nervous System
> Seizure disorders
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ZARONTIN SYRUP |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Succinamide. |
| Generic Name |
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Ethosuximide 250mg/5mL; raspberry flavor. |
| Also |
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• ZARONTIN
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| Indications |
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Absence seizures. |
| Children |
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Under 3 yrs: not recommended. 3–6 yrs: initially 250mg daily. Over 6 yrs: initially 500mg daily. Increase both every 4–7 days by 250mg daily according to response; max 1.5g daily in divided doses. Usual maintenance: 20mg/kg/day in divided doses. |
| Adults |
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Initially: 500mg daily. Increase every 4–7 days by 250mg daily according to response; max 1.5g daily in divided doses. |
| Precautions |
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Impaired hepatic or renal function. Change dose gradually. May precipitate tonic-clonic seizures. Monitor blood, urine and liver tests. Pregnancy (Cat.D). |
| Interactions |
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Monitor phenytoin, phenobarbital, valproic acid, others. |
| Adverse Reactions |
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Blood dyscrasias, drowsiness, ataxia, dizziness, hepatic, renal, behavioral, psychological and GI disorders, SLE, Stevens-Johnson syndrome, headache, rash, gingival hyperplasia. |
| How Supplied |
Caps—100
Syrup—pt |
| Additional Resources |
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• Related Prescribing Note |
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