Monograph Details
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Central Nervous System
> Seizure disorders
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VALIUM INJECTION |
| Manufacturer |
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Roche Laboratories |
| Legal Classification |
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CIV |
| Pharmacological Class |
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Benzodiazepine. |
| Generic Name |
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Diazepam 5mg/mL; contains propylene glycol 40%, ethyl and benzyl alcohol. |
| Also |
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• VALIUM
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| Indications |
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Adjunct in status epilepticus and recurrent seizures. |
| Children |
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Max 0.25mg/kg over 3 minutes; if no response after 3rd dose consider adjunctive therapy. Age <30 days: not recommended. 30 days–5 years: 0.2–0.5mg slow IV every 2–5 minutes; max 5mg. >5 years: 1mg slow IV every 2–5 minutes; max 10mg. Repeat in 2–4 hours if needed. Do not use small vein. |
| Adults |
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Initially 5–10mg slow IV (5mg/min). May repeat every 10–15 minutes; max 30mg. Repeat in 2–4 hours if needed. Do not dilute. May give IM if IV impossible. Do not use small vein. |
| Contraindications |
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Acute narrow-angle glaucoma. |
| Precautions |
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Not for use in untreated open-angle glaucoma. Inj not for use in shock, coma, acute alcohol intoxication, or obstetrical conditions. Discontinue if paradoxical reaction occurs. Drug or alcohol abuse. Depression. Suicidal tendencies. Renal or liver dysfunction. Avoid abrupt cessation. May increase tonic-clonic seizures. Reevaluate periodically. Monitor blood counts, liver function. Elderly. Debilitated. Psychosis, pregnancy, nursing mothers: not recommended. |
| Interactions |
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Potentiates CNS depression with alcohol, other CNS depressants (consider reducing opioid doses by at least ⅓). Increased serum levels with cimetidine. Potentiated by sertraline. Inj: hypotension, muscle weakness with narcotics, barbiturates, alcohol. |
| Adverse Reactions |
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CNS depression, ataxia, memory impairment, paradoxical excitement, salivation changes, neutropenia, jaundice. Inj: apnea, cardiac arrest, venous thrombosis, phlebitis, status epilepticus (when treating petit mal). |
| How Supplied |
Tabs 2mg—100
Tabs 5mg, 10mg—100, 500
Vials (10mL)—1 |
| Additional Resources |
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• Related Prescribing Note |
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