Monograph Details
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Central Nervous System
> Seizure disorders
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NEURONTIN ORAL SOLN |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Generic Name |
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Gabapentin 250mg/5mL; strawberry-anise flavor. |
| Also |
• NEURONTIN CAPSULES
• NEURONTIN TABLETS
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| Indications |
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Adjunct in partial seizures. |
| Children |
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<3yrs: not recommended. Give in 3 divided doses; max 12 hrs between doses; titrate over 3 days. 3–12 yrs: initially 10–15mg/kg per day. 3–4 yrs: titrate to 40mg/kg per day. ≥5yrs: titrate to 25–35mg/kg per day. Max 50mg/kg per day. Renal impairment: not recommended. |
| Adults |
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Add or remove other AEDs over at least 1 week. Initially 300mg three times daily. Usual range: 900–1800mg/day in 3 divided doses; max 2.4g/day (up to 3.6g/day has been used short-term; see literature); max 12 hrs between doses. Renal dysfunction: CrCl 30–59mL/min: 400–1400mg/day twice daily; CrCl 15–29mL/min: 200–700mg once daily; CrCl ≤15mL/min: 100–300mg once daily (see literature); hemodialysis: 125–350mg after session. |
| Precautions |
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Renal dysfunction. Suicidal tendencies (monitor). Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Potentiates CNS depression with alcohol, morphine, other CNS depressants. Give 2 hrs after antacids. May antagonize hydrocodone. May interfere with some urine protein tests (eg, Multistix-SG). |
| Adverse Reactions |
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Somnolence, dizziness, ataxia, fatigue, nystagmus, visual disturbances, tremor, dyspepsia, dysarthria, amnesia, back pain, edema, dry mouth or throat, constipation, twitching, pruritus; children also: emotional lability, thought disorder, hyperkinesia, hostility. |
| How Supplied |
Caps, tabs—100
Soln—470mL |
| Additional Resources |
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• Related Prescribing Note |
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