Monograph Details
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Central Nervous System
> Seizure disorders
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MYSOLINE |
| Manufacturer |
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Valeant Pharmaceuticals, Inc |
| Legal Classification |
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Rx
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| Generic Name |
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Primidone 50mg, 250mg; scored tabs. |
| Indications |
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Tonic-clonic, focal and psychomotor seizures. |
| Children |
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<8 yrs: initially 50mg at bedtime. On day 4, increase if needed to 50mg twice daily. On day 7, to 100mg twice daily. On day 10, to 125–250mg 3 times daily. Usual maintenance: 100–250mg 3 times daily or 10–25mg/kg/day in divided doses. ≥8 yrs: as adult. |
| Adults |
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Initially: 100–125mg at bedtime. Increase every 3 days if needed by 100–125mg daily to 3 times daily on day 7. On day 10, increase to 250mg 3 times daily; max 2g daily in divided doses. |
| Contraindications |
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Porphyria. Barbiturate hypersensitivity. |
| Precautions |
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Impaired liver function. Change dose gradually. Monitor blood counts, electrolytes. Pregnancy. Nursing mothers. |
| Interactions |
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Potentiated with alcohol and other CNS depressants. Antagonizes oral anticoagulants and contraceptives, steroids, Vit. K and D, griseofulvin, doxycycline. Variable effects with phenytoin, valproic acid, divalproex. Potentiated by MAOIs. Antagonizes tricyclic antidepressants. |
| Adverse Reactions |
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Drowsiness, ataxia, dizziness, nystagmus, neonatal hemorrhage and withdrawal, nausea, vomiting, rash, megaloblastic anemia sensitive to folic acid, emotional disorders, impotence. |
| How Supplied |
Tabs 50mg—100, 500
250mg—100, 1000 |
| Additional Resources |
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• Related Prescribing Note |
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