Monograph Details
|
|
Central Nervous System
> Seizure disorders
|
|
KLONOPIN |
| Manufacturer |
|
Roche Laboratories |
| Legal Classification |
|
CIV |
| Pharmacological Class |
|
Benzodiazepine. |
| Generic Name |
|
Clonazepam 0.5mg+, 1mg, 2mg; tabs; +scored. |
| Also |
|
• KLONOPIN WAFERS
|
| Indications |
|
Lennox-Gastaut syndrome, akinetic and myoclonic seizures. Absence seizures refractory to succinimides. |
| Children |
|
<10yrs or <30kg: initially 0.01–0.03mg/kg per day, but not >0.05mg/kg per day in 2–3 divided doses. Increase if needed every 3 days by 0.25–0.5mg daily. Maintenance: 0.1–0.2mg/kg per day in 3 equally divided doses. Wafers: dissolve in mouth; swallow with or without water. |
| Adults |
|
Initially up to 0.5mg 3 times daily. Increase if needed every 3 days by 0.5–1mg daily; max 20mg daily. Wafers: dissolve in mouth; swallow with or without water. |
| Contraindications |
|
Significant liver disease. Acute narrow-angle glaucoma. |
| Precautions |
|
May increase or precipitate tonic-clonic seizures. Chronic respiratory disease. Renal impairment. Avoid abrupt cessation. Monitor blood counts, liver function. Elderly. Labor & delivery, pregnancy (Cat.D), nursing mothers: not recommended. |
| Interactions |
|
Potentiates CNS depression with alcohol, other CNS depressants. Adjust anticonvulsants if needed. Absence seizures with valproate. Caution with drugs that inhibit CYP3A (eg, azole antifungals). Antagonized by CYP450 inducers (eg, phenytoin, carbamazepine, phenobarbital). Wafers may be antagonized by propantheline. |
| Adverse Reactions |
|
CNS effects (esp. depression), hypersalivation, liver disorders, GI upset, blood dyscrasias, paradoxical reactions. |
| How Supplied |
Tabs—100
Wafers—60 |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
