Monograph Details
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Central Nervous System
> Seizure disorders
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KEPPRA XR |
| Manufacturer |
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UCB Inc. |
| Legal Classification |
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Rx
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| Generic Name |
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Levetiracetam 500mg; ext-rel tabs. |
| Also |
• KEPPRA
• KEPPRA INJECTION
• KEPPRA ORAL SOLUTION
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| Indications |
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Adjunct in partial onset seizures in patients ≥16yrs old. |
| Children |
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<16yrs: not recommended. |
| Adults |
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≥16yrs: Initially 1g once daily; may increase at 2-week intervals in increments of 1g/day; max 3g/day. Renal impairment: CrCl 50–80mL/min: 1–2g every 24 hours; CrCl 30–50mL/min: 500mg–1.5g every 24 hours; CrCl <30mL/min: 500mg–1g every 24 hours; ESRD patients on dialysis: use immediate-release levetiracetam. |
| Precautions |
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Renal impairment. Suicidal tendencies (monitor). Avoid abrupt cessation. Elderly (consider monitoring renal function). Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Adverse Reactions |
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Somnolence, asthenia, infection, dizziness, coordination difficulties (eg, ataxia, abnormal gait), mood and behavioral abnormalities (eg, irritability, anger, depression, anxiety, apathy), neck pain, pharyngitis, hematologic abnormalities; rare: psychotic symptoms. Children: also accidental injury, hostility, nervousness. XR: also nausea. |
| Extra Text |
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Note: Register pregnant patients exposed to levetiracetam by calling (888) 537-7734. |
| How Supplied |
Tabs 250mg, 500mg, 750mg—120
1000mg—60
XR—60
Soln—pt
Single-use vials (5mL)—10 |
| Additional Resources |
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• Related Prescribing Note |
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