Monograph Details
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Central Nervous System
> Seizure disorders
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Diazepam oral solution |
| Manufacturer |
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Roxane Laboratories, Inc. |
| Legal Classification |
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CIV |
| Pharmacological Class |
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Benzodiazepine. |
| Generic Name |
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Diazepam 5mg; per 5mL; wintergreen-spice flavor. |
| Also |
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• Diazepam INTENSOL
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| Indications |
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Adjunct in convulsive disorders. |
| Children |
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Intensol: mix with liquid or semi-solid food. <6months: not recommended. >6months: 1–2.5mg 3–4 times daily; increase gradually. |
| Adults |
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Intensol: Mix with liquid or semi-solid food. 2–10mg 2–4 times daily. Elderly, debilitated: initially 2–2.5mg 1–2 times daily; increase gradually. |
| Contraindications |
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Acute narrow angle glaucoma. |
| Precautions |
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Not for use in untreated open-angle glaucoma. Avoid abrupt cessation. Discontinue if paradoxical reaction occurs. Drug or alcohol abuse. Depression. Suicidal tendencies. Renal or hepatic dysfunction. May increase severity of seizures. Reevaluate periodically. Monitor blood counts, liver function. Elderly. Debilitated. Psychosis, pregnancy, nursing mothers: not recommended. |
| Interactions |
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Potentiates CNS depression with alcohol, other CNS depressants (consider reducing opioid doses by at least ⅓). Increased serum levels with cimetidine. May be potentiated by phenothiazines, narcotics, barbiturates, MAOIs, other antidepressants. |
| Adverse Reactions |
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CNS depression, ataxia, memory impairment, paradoxical excitement, salivation changes, neutropenia, jaundice. |
| How Supplied |
Soln—500mL
Intensol—30mL (w. dropper) |
| Additional Resources |
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• Related Prescribing Note |
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