Monograph Details
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Central Nervous System
> Psychosis
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Trifluoperazine |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Piperazine phenothiazine. |
| Generic Name |
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Trifluoperazine (as HCl) 1mg, 2mg, 5mg, 10mg; tabs. |
| Indications |
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Psychosis. |
| Children |
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<6yrs: not recommended. ≥6yrs (under close supervision): initially 1mg 1–2 times a day. Usual max 15mg/day. |
| Adults |
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Initially: 2–5mg twice daily. Usual range: 15–20mg/day. |
| Contraindications |
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Coma. CNS or bone marrow depression. Blood dyscrasias. Liver disease. |
| Precautions |
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Discontinue at least 48 hrs before to at least 24 hrs after myelography. Cardiovascular disease. Epilepsy. Glaucoma. History of breast cancer. Exposure to extreme heat. Monitor blood, liver, and visual function. Mental retardation. Elderly. Pregnancy, nursing mothers: not recommended. |
| Interactions |
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Potentiates CNS depression with alcohol, other CNS depressants. Potentiates phenytoin, propranolol, α-blockers. May be potentiated by propranolol. Antagonizes guanethidine, oral anticoagulants. Antagonized by anticholinergics. Orthostatic hypotension with thiazides. May cause false (+) PKU test. Adjust antiepileptic drugs. |
| Adverse Reactions |
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Tardive dyskinesia, drowsiness, blood dyscrasias, jaundice, hypotension, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, anticholinergic effects, insomnia, extrapyramidal reactions, agitation, photosensitivity, neuroleptic malignant syndrome. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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