Monograph Details
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Central Nervous System
> Psychosis
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THORAZINE SYRUP |
| Manufacturer |
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GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
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Rx
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| Generic Name |
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Chlorpromazine HCl 10mg/5mL; orange-custard flavor. |
| Also |
• THORAZINE
• THORAZINE INJ
• THORAZINE SUPPOSITORIES
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| Indications |
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Psychosis. Mania. Intractable hiccups. Severe childhood behavior problems. Tetany. |
| Children |
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<6months: not recommended. ≥6 months: initially 0.25mg/lb every 4–6 hrs as needed. Rectally: 0.5mg/lb every 6–8 hrs as needed. |
| Adults |
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Psychosis: initially 10mg 3–4 (or 25mg 2–3) times daily; may increase semiweekly by 25–50mg daily. Hiccups: 25–50mg 3–4 times daily. Severe psychosis: initially 25mg 3 times daily; may increase semiweekly by 20–50mg/day. |
| Contraindications |
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Coma. CNS or bone marrow depression. Reye's syndrome. |
| Precautions |
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Discontinue 48 hrs before to 24 hrs after myelography. Cardiovascular, respiratory, renal, or liver disease. Epilepsy. Glaucoma. History of breast cancer. Exposure to extreme heat or organophosphates. Asthma (inj). Monitor blood, liver, and ocular function. Elderly. Pregnancy, nursing mothers: not recommended. |
| Interactions |
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Potentiates phenytoin, alcohol, other CNS depressants, propranolol. Potentiated by propranolol. Antagonized by anticholinergics. Atropine. Decreased guanethidine, anticoagulant effects. |
| Adverse Reactions |
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Tardive dyskinesia, drowsiness, jaundice, blood dyscrasias, hypotension, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, skin pigmentation, anticholinergic effects, insomnia, extrapyramidal reactions, neuroleptic malignant syndrome. |
| How Supplied |
Tabs—100
Syrup—4oz
Supp—12
Amp (1mL, 2mL)—10
Vial (10mL)—1 |
| Additional Resources |
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• Related Prescribing Note |
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