Monograph Details
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Central Nervous System
> Psychosis
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Prochlorperazine |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Piperazine phenothiazine. |
| Generic Name |
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Prochlorperazine (as maleate) 5mg, 10mg; tabs. |
| Also |
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• Prochlorperazine Suppositories
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| Indications |
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Schizophrenia. |
| Children |
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<2yrs or <20lbs: not recommended. 2yrs–5yrs: Initially 2½mg 2–3 times daily; max 10mg first day, then max 20mg/day. 6–12yrs: Initially 2½mg 2–3 times daily; max 10mg first day, then max 25mg/day. |
| Adults |
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Mild conditions: 5–10mg 3–4 times daily. Moderate-to-severe conditions (closely supervised): Initially 10mg 3–4 times daily, may increase gradually every 2–3 days; usual range 50–75mg/day. Severe conditions: usual range 100–150mg daily. |
| Contraindications |
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Coma. CNS depression. Pediatric surgery. Children <2yrs or <20lbs. |
| Precautions |
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Discontinue 48 hrs before to 24 hrs after myelography. Cardiovascular disease. Epilepsy. Bone marrow depression. Reye's syndrome. Glaucoma. History of breast cancer. Exposure to extreme heat. Monitor blood, liver, and ocular function. Write Rx using fractions rather than decimals. Children with acute illness or dehydration. Debilitated. Elderly. Pregnancy, nursing mothers: not recommended. |
| Interactions |
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Potentiates CNS depression with alcohol, other CNS depressants. Potentiates α-blockers. Levels of both drugs increased with propranolol. May potentiate phenytoin; monitor for toxicity. Adjust anticonvulsant doses. May antagonize oral anticoagulants. Hypotension potentiated with thiazide diuretics. Antagonized by anticholinergics. Decreases guanethidine effects. Monitor for neurologic toxicity with lithium; discontinue if occurs. May cause false (+) PKU test. |
| Adverse Reactions |
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Drowsiness, dizziness, amenorrhea, blurred vision, other anticholinergic effects, skin reactions, hypotension, cholestatic jaundice, photosensitivity, leukopenia, agranulocytosis, neuroleptic malignant syndrome, agitation, insomnia, dystonias, extrapyramidal reactions, pseudoparkinsonism, tardive dyskinesia, may mask emetic signs of disease, lowered seizure threshold, EKG changes, aspiration, deep sleep, hyperprolactinemia, paradoxical excitement in children. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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