Monograph Details
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Central Nervous System
> Psychosis
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Perphenazine |
| Manufacturer |
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Various generic manufacturers |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Piperazinyl phenothiazine. |
| Generic Name |
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Perphenazine 2mg, 4mg, 8mg, 16mg; tabs. |
| Indications |
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Manifestations of psychotic disorders. |
| Children |
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Not recommended. |
| Adults |
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Nonhospitalized: initially 4–8mg 3 times daily; then reduce to lowest effective dose. Hospitalized: 8–16mg 2–4 times daily; max 64mg per day. |
| Contraindications |
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Coma. Concomitant large doses of CNS depressants. Blood dyscrasias. Bone marrow depression. Liver damage. Subcortical brain damage. |
| Precautions |
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CNS depression. Epilepsy. Cardiovascular disease. Respiratory disorders. History of breast cancer. Pheochromocytoma. Avoid sun, exposure to extreme heat or phosphorus insecticides. Surgery: consider lower anesthetic dose. Monitor blood, hepatic, and renal function. Write Rx for smallest practical amounts. Reevaluate periodically. Debilitated. Elderly. Pregnancy, nursing mothers: not recommended. |
| Interactions |
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Potentiates CNS depression with alcohol, other CNS depressants. Adjust anticonvulsant doses. Additive anticholinergic effects with atropine or related-drugs. |
| Adverse Reactions |
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Tardive dyskinesia, drowsiness, jaundice, blood dyscrasias, hypotension, ECG changes, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, skin pigmentation, anticholinergic effects, insomnia, adynamic ileus, hyperprolactinemia, extrapyramidal reactions, neuroleptic malignant syndrome. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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