Monograph Details
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Central Nervous System
> Psychosis
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INVEGA |
| Manufacturer |
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Janssen Pharmaceutica Products, LP |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Benzisoxazole. |
| Generic Name |
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Paliperidone 3mg, 6mg, 9mg; ext-rel tabs. |
| Indications |
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Acute and maintenance treatment of schizophrenia. |
| Children |
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<18yrs: not recommended. |
| Adults |
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Swallow whole. ≥18yrs: 6mg once daily in AM; may increase in increments of 3mg/day at intervals of >5 days if needed. Max 12mg/day. Renal impairment: CrCl ≥50–<80mL/min: max 6mg/day; CrCl 10–<50mL/min: max 3mg/day. |
| Precautions |
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Avoid in congenital long QT syndrome, cardiac arrhythmias. Diabetes risk factors (obtain baseline fasting blood sugar). Monitor for hyperglycemia. Pre-existing severe GI narrowing: not recommended. Cardio- or cerebrovascular disease. Orthostatic hypotension. History of seizures. Patients at risk for aspiration pneumonia. Renal insufficiency. Severe hepatic impairment. Exposure to extreme temperatures. May have antiemetic effect. Suicidal patients. Reevaluate periodically. Elderly (not for dementia-related psychosis); consider monitoring renal function and for orthostatic effects. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Avoid alcohol, drugs that prolong QT interval (eg, Class 1A and Class III antiarrhythmics, chlorpromazine, thioridazine, gatifloxacin, moxifloxacin). Caution with other CNS drugs. May antagonize levodopa, other dopamine agonists. |
| Adverse Reactions |
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Tachycardia, extrapyramidal effects, akathisia, dizziness, anxiety, somnolence, headache, GI upset; may cause neuroleptic malignant syndrome, tardive dyskinesia, QT prolongation, hyperglycemia, orthostatic hypotension, syncope, hyperprolactinemia, priapism. |
| How Supplied |
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Tabs—30, 350 |
| Additional Resources |
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• Related Prescribing Note |
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