Monograph Details
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Central Nervous System
> Psychosis
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ABILIFY |
| Manufacturer |
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BMS/Otsuka Partnership |
| Legal Classification |
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Rx
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| Generic Name |
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Aripiprazole 2mg, 5mg, 10mg, 15mg, 20mg, 30mg; tabs. |
| Also |
• ABILIFY DISCMELT
• ABILIFY INJECTION
• ABILIFY ORAL SOLUTION
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| Indications |
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Schizophrenia. |
| Children |
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<13yrs: not recommended. 13–17yrs: initially 2mg daily, then increase to 5mg after 2 days, then increase to target dose of 10mg after 2 days. Subsequent doses may be adjusted by increments of 5mg/day; max 30mg/day. Maintenance: continue at lowest dose to maintain remission; see literature. |
| Adults |
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Tabs and soln may be interchanged on a mg–to–mg basis up to 25mg; 30mg as tablet is equivalent to 25mg oral soln. Discmelt: Dissolve on tongue; take without liquids. Initially 10mg or 15mg once daily; may increase at intervals of at least 2 weeks; usual maintenance 15mg/day; max 30mg/day. Reduce aripiprazole dose by at least ½ with CYP3A4 inhibitors or CYP2D6 inhibitors. Double aripiprazole dose (max 30mg/day) with CYP3A4 inducers. Adjust dose to normal range when these drugs are withdrawn. |
| Precautions |
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Cardio- or cerebrovascular disease. Risk of hypotension, aspiration pneumonia, seizures, or diabetes (do baseline fasting blood sugar). Exposure to extreme heat. Dehydration. Reevaluate periodically. Monitor for hyperglycemia. Exclude neuroleptic malignant syndrome if fever occurs. Suicidal tendencies. Write Rx for smallest practical amount. Elderly (not for dementia-related psychosis). Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Avoid alcohol. Caution with other centrally-acting drugs. Potentiates antihypertensives. Levels may be reduced by CYP3A4 inducers (eg, carbamazepine). Levels may be increased by CYP3A4 inhibitors (eg, ketoconazole) or CYP2D6 inhibitors (eg, quinidine, fluoxetine, paroxetine). Caution with drugs that interfere with temperature regulation (eg, anticholinergics). |
| Adverse Reactions |
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Headache, anxiety, insomnia, GI upset, somnolence, akathisia, orthostatic hypotension, asthenia, blurred vision, tremor, neuroleptic malignant syndrome, tardive dyskinesia, weight gain, others. Inj: local reactions. |
| How Supplied |
Tabs 2mg—30
5mg, 10mg, 15mg, 20mg, 30mg—30, 100
Oral soln (w. dosing cup)—150mL
Discmelt—30
Single use vials—1 |
| Additional Resources |
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• Related Prescribing Note |
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