Monograph Details
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Central Nervous System
> Parkinsonism
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Trihexyphenidyl Elixir |
| Manufacturer |
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Wyeth Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Anticholinergic. |
| Generic Name |
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Trihexyphenidyl HCl 2mg/5mL; lime-mint flavor; contains alcohol. |
| Also |
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• Trihexyphenidyl Tabs
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| Indications |
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Adjunct in Parkinsonism. Drug-induced extrapyramidal symptoms (EPS). |
| Children |
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Not recommended. |
| Adults |
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Take with food. Give in 3–4 divided doses. Parkinsonism: 1mg on day 1, may increase by 2mg every 3–5 days; usual max 6–15mg/day. Concomitant levodopa: 3–6mg/day and reduce levodopa dose. EPS: 1mg on day 1; range 5–15mg/day. |
| Contraindications |
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Tardive dyskinesia. Narrow-angle glaucoma. |
| Precautions |
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Cardiovascular, renal, or hepatic disorders. Hypertension. Psychosis. GI or GU obstruction. Exposure to extreme heat. Monitor intraocular pressure. Avoid abrupt cessation. Nursing mothers. |
| Interactions |
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Potentiates CNS depression with alcohol, CNS depressants. Antagonizes psychotropics. Additive anticholinergic effects with MAOIs. Paralytic ileus with phenothiazines, tricyclic antidepressants. |
| Adverse Reactions |
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Anticholinergic and antihistaminic effects, confusion, anhidrosis, excitement, nausea, vomiting, angle-closure glaucoma, hallucinations, neuroleptic malignant syndrome, heat stroke, drowsiness. |
| How Supplied |
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Contact supplier. |
| Additional Resources |
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• Related Prescribing Note |
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