Monograph Details
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Central Nervous System
> Parkinsonism
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SYMMETREL |
| Manufacturer |
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Endo Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Dopamine agonist. |
| Generic Name |
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Amantadine HCl 100mg; tabs. |
| Also |
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• SYMMETREL SYRUP
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| Indications |
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Parkinsonism. Drug-induced extrapyramidal reactions. |
| Children |
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Not recommended. |
| Adults |
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Parkinsonism monotherapy: initially 100mg twice daily, may increase after 1–2 weeks by 100mg daily. Serious associated illness or high doses of other antiparkinson drugs: 100mg once daily, may increase after 1 to several weeks to 100mg twice daily; max 400mg/day in divided doses. Extrapyramidal disorders: 100mg twice daily; max 300mg/day in divided doses. Renal dysfunction: reduce dose; see literature. |
| Precautions |
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Adjust dose gradually. History of seizures. Heart failure. Orthostatic hypotension. Peripheral edema. Renal (CrCl <50mL/min) or hepatic dysfunction. Psychiatric disorders. Suicidal ideation. History of recurrent eczematoid rash. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Caution with CNS stimulants. Thioridazine may worsen tremor in elderly patients with parkinsonism. |
| Adverse Reactions |
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Neuroleptic malignant syndrome (when drug is withdrawn or dose is reduced), nausea, dizziness, insomnia, heart failure, anxiety, irritability, hallucinations, confusion, anorexia, anticholinergic effects, constipation, ataxia, livedo reticularis, peripheral edema, orthostatic hypotension, headache, somnolence, dream abnormality, diarrhea, fatigue. |
| How Supplied |
Tabs—100
Syrup—pt |
| Additional Resources |
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• Related Prescribing Note |
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