Monograph Details
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Central Nervous System
> Parkinsonism
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PARLODEL |
| Manufacturer |
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Novartis Pharmaceuticals Corp |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Dopamine agonist (ergot deriv). |
| Generic Name |
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Bromocriptine (as mesylate) 2.5mg; scored tabs. |
| Also |
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• PARLODEL CAPSULES
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| Indications |
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Parkinsonism. |
| Children |
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Not recommended. |
| Adults |
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Take with food. Initially 1.25mg twice daily. May increase every 2–4 weeks by 2.5mg/day; max 100mg/day. Maintain levodopa dose at first. |
| Contraindications |
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Parkinsonism refractory to levodopa. Uncontrolled hypertension. Hypertension of pregnancy. Postpartum lactation. Other ergots. |
| Precautions |
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Dementia. MI. Arrhythmias. Renal or hepatic disease. Raynaud's syndrome. Discontinue if hypertension, severe headache, or CNS toxicity occurs. Psychosis. Peptic ulcer. GI bleed. Monitor hepatic, cardiovascular, renal function, BP, blood counts. Post-partum use if history of severe cardiovascular disease (eg, coronary artery disease). Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
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See Contraindications. Avoid phenothiazines, alcohol. Potentiates antihypertensives. Caution with dopamine antagonists, butyrophenones, drugs that affect BP. Antagonized by phenothiazines, haloperidol, metoclopramide, pimozide. |
| Adverse Reactions |
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GI upset, involuntary movements, hallucinations, confusion, on-off phenomenon, dizziness, drowsiness, insomnia, syncope, asthenia, visual disturbances, ataxia, hypotension; rarely: hypertension, seizure, stroke, MI. |
| How Supplied |
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Tabs, caps—30, 100 |
| Additional Resources |
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• Related Prescribing Note |
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