Monograph Details
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Central Nervous System
> Parkinsonism
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MIRAPEX |
| Manufacturer |
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Boehringer Ingelheim Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Dopamine agonist (non-ergot). |
| Generic Name |
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Pramipexole dihydrochloride 0.125mg, 0.25mg+, 0.5mg+, 0.75mg, 1mg+, 1.5mg+; tabs; +scored. |
| Indications |
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Idiopathic Parkinson's disease. |
| Children |
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Not recommended. |
| Adults |
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May take with food. Gradually increase from initial dose at intervals of 5–7 days. Initially 0.125mg three times daily; max 1.5mg three times daily. Renal impairment: CrCl 35–59mL/min: initially 0.125mg twice daily; max 1.5mg twice daily. CrCl 15–34mL/min: initially 0.125mg once daily; max 1.5mg once daily. CrCl <15mL/min, hemodialysis: not recommended. |
| Precautions |
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See literature. Consider discontinuing if excessive daytime sleepiness or if sudden onset of sleep during daily activities occurs. Monitor for drowsiness or sleepiness, and for orthostatic hypotension. Renal disease. Sleep disorders. Dyskinesia. Avoid abrupt cessation (withdraw over 1 week). Elderly may have higher risk of hallucinations. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Consider reducing concomitant levodopa dose. Pramipexole levels increased by cimetidine, possibly other renally-excreted basic drugs (eg, ranitidine, diltiazem, triamterene, verapamil, quinidine, quinine). Caution with alcohol, other CNS depressants. May be antagonized by dopamine antagonists (eg, neuroleptics, metoclopramide). |
| Adverse Reactions |
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Early disease: nausea, dizziness, somnolence (including sudden sleep onset), insomnia, constipation, asthenia, hallucinations, accidental injury, dyspepsia, others. Late disease: postural hypotension, dyskinesia, extrapyramidal syndrome, insomnia, dizziness, hallucinations, accidental injury, dream abnormalities, confusion, constipation, asthenia, somnolence (including sudden sleep onset), dystonia, abnormal gait, hypertonia, dry mouth, amnesia, urinary frequency, leg cramps, others. |
| How Supplied |
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Tabs—90 |
| Additional Resources |
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• Related Prescribing Note |
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