Monograph Details
|
|
Central Nervous System
> Mood disorders
|
|
PAMELOR ORAL SOLUTION |
| Manufacturer |
|
Mallinckrodt, Inc. |
| Legal Classification |
|
Rx
|
| Pharmacological Class |
|
Tricyclic. |
| Generic Name |
|
Nortriptyline (as HCl) 10mg/5mL; contains alcohol 4%. |
| Also |
|
• PAMELOR
|
| Indications |
|
Depression. |
| Children |
|
Not recommended. |
| Adults |
|
Initially 25mg 3–4 times daily; max 150mg/day. Elderly and adolescents: 30–50mg/day in single or divided doses. |
| Contraindications |
|
During or within 14 days of MAOIs. Acute post-MI. |
| Precautions |
|
Urinary retention. Glaucoma. Cardiovascular disease. Epilepsy. Suicidal tendencies. ECT. Mania/hypomania. Bipolar disorder. Psychosis. Diabetes. Hyperthyroidism. Liver disorders. Monitor plasma levels if dose >100mg/day. Elderly. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
|
See Contraindications. Hyperpyretic crisis, convulsions, death with MAOIs. Potentiates alcohol, sympathomimetics. CNS stimulation with reserpine. Potentiated by CYP2D6 inhibitors; monitor plasma levels with cimetidine, SSRIs, phenothiazines, type 1C antiarrhythmics (eg, quinidine). Antagonized by barbiturates, carbamazepine, phenytoin. Paralytic ileus, hyperpyrexia with anticholinergics. Blocks guanethidine. |
| Adverse Reactions |
|
Drowsiness, anticholinergic effects, CNS overstimulation, arrhythmias, extrapyramidal symptoms, hypo- or hypertension, nausea, fatigue, rash, increased perspiration, headache, changes in blood sugar, photosensitivity, edema, blood dyscrasias, jaundice. |
| How Supplied |
Caps—100
Soln—pt |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
