Monograph Details
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Central Nervous System
> Mood disorders
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NORPRAMIN |
| Manufacturer |
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Sanofi Aventis |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Tricyclic. |
| Generic Name |
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Desipramine HCl 10mg, 25mg, 50mg, 75mg, 100mg, 150mg; tabs. |
| Indications |
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Depression. |
| Children |
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Not recommended. |
| Adults |
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100–200mg daily in single or divided doses; max 300mg/day. Hospitalize initially if dose is 300mg/day; monitor ECG. Elderly and adolescents: 25–100mg daily; max 150mg/day. |
| Contraindications |
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During or within 14 days of MAOIs. Acute post-MI. |
| Precautions |
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Renal dysfunction. Urinary retention. Glaucoma. Cardiovascular disease. Epilepsy. ECT. Psychosis. Mania/hypomania. Bipolar disorder. Hyperthyroidism. Diabetes. Hepatic disorders. Monitor blood in prolonged use. Discontinue before surgery. Write Rx for smallest practical amount. Elderly. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Hyperpyretic crisis, convulsions, death with MAOIs. Potentiates alcohol, sympathomimetics, benzodiazepines, other CNS depressants. Potentiated by CYP2D6 inhibitors; monitor plasma levels with cimetidine, SSRIs, phenothiazines, type 1C antiarrhythmics (eg, quinidine). Antagonized by barbiturates, carbamazepine, phenytoin. Paralytic ileus, hyperpyrexia with anticholinergics. Blocks guanethidine. |
| Adverse Reactions |
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Drowsiness, anticholinergic effects, CNS overstimulation, arrhythmias, extrapyramidal symptoms, hypo- or hypertension, nausea, fatigue, rash, hyperhidrosis, headache, changes in blood sugar, photosensitivity, edema, blood dyscrasias, jaundice. |
| How Supplied |
Tabs—100
150mg—50 |
| Additional Resources |
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• Related Prescribing Note |
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