Monograph Details
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Central Nervous System
> Mood disorders
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ABILIFY INJECTION |
| Manufacturer |
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BMS/Otsuka Partnership |
| Legal Classification |
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Rx
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| Generic Name |
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Aripiprazole 7.5mg/mL; soln for IM use only. |
| Also |
• ABILIFY
• ABILIFY DISCMELT
• ABILIFY ORAL SOLUTION
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| Indications |
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Treatment of agitation associated with acute manic or mixed episodes in bipolar disorder. |
| Children |
Not recommended.
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| Adults |
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9.75mg IM, if 2nd dose is needed, may repeat after 2 hours; max 30mg/day. Switch to oral form as soon as possible. Reduce aripiprazole dose by at least ½ with CYP3A4 inhibitors or CYP2D6 inhibitors. Double aripiprazole dose (max 30mg/day) with CYP3A4 inducers. Adjust dose to normal range when these drugs are withdrawn. |
| Precautions |
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Cardio- or cerebrovascular disease. Risk of hypotension, aspiration pneumonia, seizures, or diabetes (do baseline fasting blood sugar). Exposure to extreme heat. Dehydration. Reevaluate periodically. Monitor for hyperglycemia. Exclude neuroleptic malignant syndrome if fever occurs. Suicidal tendencies. Write Rx for smallest practical amount. Elderly (not for dementia-related psychosis). Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Avoid alcohol. Caution with other centrally-acting drugs. Potentiates antihypertensives. Levels may be reduced by CYP3A4 inducers (eg, carbamazepine). Levels may be increased by CYP3A4 inhibitors (eg, ketoconazole) or CYP2D6 inhibitors (eg, quinidine, fluoxetine, paroxetine). Caution with drugs that interfere with temperature regulation (eg, anticholinergics). |
| Adverse Reactions |
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Headache, anxiety, insomnia, GI upset, somnolence, akathisia, orthostatic hypotension, asthenia, blurred vision, tremor, neuroleptic malignant syndrome, tardive dyskinesia, weight gain, others. Inj: local reactions. |
| How Supplied |
Tabs 2mg—30
5mg, 10mg, 15mg, 20mg, 30mg—30, 100
Oral soln (w. dosing cup)—150mL
Discmelt—30
Single use vials—1 |
| Additional Resources |
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• Related Prescribing Note |
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