Monograph Details
|
|
Central Nervous System
> Insomnia
|
|
Estazolam |
| Manufacturer |
|
Various generic manufacturers |
| Legal Classification |
|
CIV |
| Pharmacological Class |
|
Benzodiazepine. |
| Generic Name |
|
Estazolam 1mg, 2mg; scored tabs. |
| Indications |
|
Short-term treatment of insomnia. |
| Children |
|
<18yrs: not recommended. |
| Adults |
|
Initially 1mg at bedtime. May increase to 2mg nightly. Small or debilitated elderly: initially 0.5mg. |
| Contraindications |
|
Concomitant ketoconazole, itraconazole. Pregnancy (Cat.X). |
| Precautions |
|
Drug or alcohol abuse. Suicidal tendencies. Depression. Renal, hepatic, or respiratory impairment. Avoid abrupt cessation after prolonged use. Elderly. Debilitated. Nursing mothers: not recommended. |
| Interactions |
|
Potentiates CNS depression with alcohol, other CNS depressants. Caution with CYP3A inhibitors (eg, nefazodone, fluvoxamine, cimetidine, diltiazem, isoniazid, other macrolides): consider dose reduction. |
| Adverse Reactions |
|
CNS depression, complex sleep-related behaviors (eg, sleep-driving), hypokinesia, dizziness, incoordination, confusion, constipation, anxiety, paradoxical excitement; anaphylaxis, angioedema. |
| How Supplied |
|
Contact supplier. |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
