Monograph Details
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Central Nervous System
> Insomnia
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AMBIEN CR |
| Manufacturer |
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Sanofi Aventis |
| Legal Classification |
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CIV |
| Pharmacological Class |
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Imidazopyridine hypnotic. |
| Generic Name |
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Zolpidem tartrate 6.25mg, 12.5mg; ext-rel tabs. |
| Also |
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• AMBIEN
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| Indications |
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Insomnia. |
| Children |
<18yrs: not recommended.
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| Adults |
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Swallow whole. 12.5mg at bedtime (take only if able to get 7–8 hours of sleep before becoming active again). Elderly, debilitated, or hepatic insufficiency: 6.25mg. Effect delayed if taken with a meal. |
| Precautions |
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Depression. Behavioral changes. Compromised respiratory function. Conditions that affect metabolism or hemodynamic response. Drug or alcohol abuse. Write Rx for smallest practical amount. Withdraw gradually. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.C for Ambien CR, Cat.B for Ambien). Nursing mothers: not recommended. |
| Interactions |
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May potentiate CNS depression with alcohol, other CNS depressants. May be potentiated by CYP3A4 inhibitors (eg, itraconazole). May be antagonized by flumazenil, CYP3A4 inducers (eg, rifampin). |
| Adverse Reactions |
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CNS effects, complex sleep-related behaviors (eg, sleep-driving), headache, GI upset, dry mouth; anaphylaxis, angioedema, others (see literature). |
| How Supplied |
Ambien CR—100, 500
Ambien—30, 100 |
| Additional Resources |
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• Related Prescribing Note |
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