Monograph Details
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Central Nervous System
> Anxiety/OCD
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ZOLOFT ORAL CONCENTRATE |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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SSRI. |
| Generic Name |
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Sertraline (as HCl) 20mg/mL; soln; contains alcohol 12%. Dilute just before administering in 4oz water, ginger ale, lemon/lime soda, lemonade, or orange juice. |
| Also |
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• ZOLOFT
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| Indications |
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Panic disorder. Posttraumatic stress disorder (PTSD). Obsessive-compulsive disorder (OCD). Social anxiety disorder. |
| Children |
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<6 years: not recommended. Give once daily (AM or PM). OCD: 6–12 years: initially 25mg/day. 13–17 years: initially 50mg/day. May increase at 1-week intervals; max 200mg/day. |
| Adults |
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Give once daily (AM or PM). Panic or social anxiety disorder, PTSD: initially 25mg/day, increase after 1 week to 50mg/day; titrate at intervals of at least 1 week. OCD: Initially 50mg/day; may increase at 1-week intervals. For all: max 200mg/day. |
| Contraindications |
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During or within 14 days of MAOIs. Concomitant pimozide. Oral soln: concomitant disulfiram. |
| Precautions |
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Monitor for mania/hypomania. Seizure disorders. Suicidal tendencies. Hepatic dysfunction (reduce dose or prolong dosing interval). Cardiac disease. Conditions that affect metabolism or hemodynamic response. Volume depleted. Reevaluate periodically in long-term use. Write Rx for smallest practical amount. Elderly. Labor & delivery. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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See Contraindications. Avoid alcohol. May potentiate or be potentiated by cimetidine, protein bound drugs (eg, warfarin, digitoxin). Caution with other CNS drugs and drugs metabolized by CYP2D6 (eg, tricyclics, flecainide, propafenone). Potentiates diazepam, tolbutamide. Monitor lithium, warfarin, tricyclics. Monitor patients on sumatriptan for serotonin syndrome (eg, weakness, incoordination, hyperreflexia). |
| Adverse Reactions |
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GI upset, insomnia, sexual dysfunction, somnolence, decreased libido, anorexia, weight loss, agitation, tremor, dry mouth, sweating, hyponatremia/SIADH (esp in elderly), weak uricosuric effect. Children: also, hyperkinesia, fever, urinary incontinence, aggressiveness, sinusitis, epistaxis, purpura. |
| How Supplied |
Tabs 25mg—50
50mg, 100mg—100, 500
Conc—60mL (w. dropper) |
| Additional Resources |
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• Related Prescribing Note |
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