Monograph Details
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Central Nervous System
> Anxiety/OCD
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XANAX |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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CIV |
| Generic Name |
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Alprazolam 0.25mg, 0.5mg, 1mg, 2mg+; scored tabs (+multi-scored). |
| Also |
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• XANAX XR
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| Indications |
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Anxiety. Panic disorder. |
| Children |
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<18yrs: not recommended. |
| Adults |
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Adjust at intervals of at least 3–4 days. ≥18yrs: Anxiety: initially 0.25–0.5mg 3 times daily; max 4mg daily in divided doses. Elderly or debilitated: initially 0.25mg 2–3 times daily. Panic disorder: initially 0.5mg 3 times daily; usual range: 5–6mg daily in divided doses; max 10mg/day. |
| Contraindications |
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Acute narrow-angle glaucoma. Concomitant itraconazole, ketoconazole. |
| Precautions |
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Not for use in untreated open-angle glaucoma. Reevaluate periodically. Change dose gradually. Withdrawal symptoms on abrupt cessation or dose reduction. Suicidal ideation. Psychosis. Mania. Renal, cardiovascular, hepatic, pulmonary dysfunction (monitor). Obesity. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.D), nursing mothers: not recommended. |
| Interactions |
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See Contraindications; other azole antifungals: not recommended. Potentiates CNS depression with alcohol, psychotropics, anticonvulsants, other CNS depressants. Potentiated by CYP3A inhibitors; reduce alprazolam dose; caution with cimetidine, nefazodone, fluvoxamine; caution with weaker CYP3A inhibitors (eg, fluoxetine, propoxyphene, oral contraceptives). Antagonized by CYP3A inducers (eg, carbamazepine). May increase levels of imipramine, desipramine. |
| Adverse Reactions |
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CNS depression; impaired memory, coordination, or attention; dysarthria, ataxia, arthralgia, dyspnea, paradoxical excitement, increased salivation, withdrawal seizures, tremors, decreased libido, sexual dysfunction. |
| How Supplied |
XR—60
Tabs 0.25mg, 0.5mg, 1mg—100, 500, 1000
2mg—100, 500 |
| Additional Resources |
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• Related Prescribing Note |
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