Monograph Details
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Central Nervous System
> Anxiety/OCD
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TRANXENE-SD HALF STRENGTH |
| Manufacturer |
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Ovation Pharmaceuticals, Inc. |
| Legal Classification |
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CIV |
| Pharmacological Class |
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Benzodiazepine. |
| Generic Name |
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Clorazepate dipotassium 11.25mg; ext-rel tabs. |
| Also |
• TRANXENE
• TRANXENE-SD
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| Indications |
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Anxiety. |
| Children |
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<9yrs: not recommended. |
| Adults |
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30mg daily in divided doses; range: 15–60mg daily in divided doses. Debilitated: initially 7.5–15mg daily in divided doses. May use SD tablets as alternative for patients stabilized on regular tabs: give SD 22.5mg once daily in place of 7.5mg 3 times daily; give SD 11.25mg once daily in place of 3.75mg 3 times daily. |
| Contraindications |
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Acute narrow-angle glaucoma. |
| Precautions |
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Drug or alcohol abuse. Suicidal tendencies. Renal or hepatic disease. Change dose gradually. Therapy for >4 months. Monitor blood counts and hepatic function. Psychosis, depression, pregnancy, nursing mothers: not recommended. |
| Interactions |
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Potentiation of CNS depression with alcohol and other CNS depressants. |
| Adverse Reactions |
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CNS depression, dizziness, ataxia, memory impairment, GI disorders, dry mouth, blurred vision, headache, hallucinations, tremor, rash, hypotension, abnormal hepatic and renal tests, decreased hematocrit. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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