Monograph Details
|
|
Central Nervous System
> Anxiety/OCD
|
|
SINEQUAN CONCENTRATE |
| Manufacturer |
|
Pfizer Labs |
| Legal Classification |
|
Rx
|
| Pharmacological Class |
|
Tricyclic. |
| Generic Name |
|
Doxepin (as HCl) 10mg/mL. |
| Also |
|
• SINEQUAN
|
| Indications |
|
Anxiety. |
| Children |
|
Not recommended. |
| Adults |
|
Soln: dilute with 4oz juice, water, or milk. Mild: 25–50mg/day. Mild to moderate: initially 75mg/day; range 75–150mg/day. Severe: max 300mg/day. May give as single (up to 150mg) or divided doses; 150mg caps for maintenance only. |
| Contraindications |
|
During or within 14 days of MAOIs. Acute post MI. Urinary retention. Glaucoma. |
| Precautions |
|
Cardiovascular disease. Epilepsy. Suicidal tendencies. Psychosis. Diabetes. Avoid abrupt cessation. Poor metabolizers (those with reduced CYP2D6 activity). Elderly. Pregnancy. Nursing mothers. |
| Interactions |
|
Hyperpyretic crisis, convulsions, death with MAOIs. Potentiates CNS depression of alcohol; cimetidine; other CYP2D6 substrates. Antagonized by barbiturates, carbamazepine, phenytoin. Paralytic ileus, hyperpyrexia with anticholinergics. May block guanethidine. |
| Adverse Reactions |
|
CNS effects (eg, drowsiness, overstimulation, extrapyramidal symptoms), anticholinergic effects, hypotension, GI upset, photosensitivity, endocrine effects. |
| How Supplied |
Caps 10mg, 25mg, 50mg, 75mg, 100mg—100
150mg—50
Conc—4oz (w. dropper) |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
