Monograph Details
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Central Nervous System
> Anxiety/OCD
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SINEQUAN |
| Manufacturer |
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Pfizer Labs |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Tricyclic. |
| Generic Name |
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Doxepin (as HCl) 10mg, 25mg, 50mg, 75mg, 100mg, 150mg; caps. |
| Also |
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• SINEQUAN CONCENTRATE
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| Indications |
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Anxiety. |
| Children |
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Not recommended. |
| Adults |
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Soln: dilute with 4oz juice, water, or milk. Mild: 25–50mg/day. Mild to moderate: initially 75mg/day; range 75–150mg/day. Severe: max 300mg/day. May give as single (up to 150mg) or divided doses; 150mg caps for maintenance only. |
| Contraindications |
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During or within 14 days of MAOIs. Acute post MI. Urinary retention. Glaucoma. |
| Precautions |
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Cardiovascular disease. Epilepsy. Suicidal tendencies. Psychosis. Diabetes. Avoid abrupt cessation. Poor metabolizers (those with reduced CYP2D6 activity). Elderly. Pregnancy. Nursing mothers. |
| Interactions |
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Hyperpyretic crisis, convulsions, death with MAOIs. Potentiates CNS depression of alcohol; cimetidine; other CYP2D6 substrates. Antagonized by barbiturates, carbamazepine, phenytoin. Paralytic ileus, hyperpyrexia with anticholinergics. May block guanethidine. |
| Adverse Reactions |
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CNS effects (eg, drowsiness, overstimulation, extrapyramidal symptoms), anticholinergic effects, hypotension, GI upset, photosensitivity, endocrine effects. |
| How Supplied |
Caps 10mg, 25mg, 50mg, 75mg, 100mg—100
150mg—50
Conc—4oz (w. dropper) |
| Additional Resources |
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• Related Prescribing Note |
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