Monograph Details
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Central Nervous System
> Anxiety/OCD
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LUVOX CR |
| Manufacturer |
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Jazz Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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SSRI. |
| Generic Name |
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Fluvoxamine maleate 100mg, 150mg; ext-rel caps. |
| Indications |
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Obsessive-compulsive disorder. Social anxiety disorder. |
| Children |
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Not recommended. |
| Adults |
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Swallow whole. ≥18yrs: initially 100mg once daily at bedtime; may increase in 50mg increments at 1-week interval; range 100–300mg/day; max 300mg/day. Hepatic impairment: initially 100mg and titrate slowly. |
| Contraindications |
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Concomitant alosetron, tizanidine, pimozide, thioridazine, ramelteon. During or within 14 days of MAOIs. |
| Precautions |
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Liver dysfunction. History of seizures (discontinue if occurs), mania/hypomania, or drug abuse. ECT. Cardiovascular disease. Diseases that affect metabolism or hemodynamic response. SIADH, edema, fluid loss, adrenal disorders, displacement syndromes (monitor electrolytes, BUN, creatinine). Reduced activity of CYP2D6. Suicidal tendencies. Reevaluate periodically. Write Rx for smallest practical amount. Avoid abrupt cessation. Elderly. Labor & delivery. Pregnancy (Cat.C); 3rd trimester: consider tapering dose. Nursing mothers: not recommended. |
| Interactions |
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See Contraindications. Prolongation of QT interval with pimozide, thioridazine. Avoid alcohol. Potentiated by other serotonergic drugs, sumatriptan, lithium, tramadol, St. John's Wort. Concomitant other SSRIs, SNRIs, or tryptophan: not recommended. Potentiates diazepam (not recommended), triazolam and alprazolam (reduce their doses by at least ½), midazolam, theophylline (reduce its dose by ⅔ and monitor), warfarin, carbamazepine, tricyclic antidepressants (reduce their doses and monitor), propranolol, metoprolol (reduce their doses), clozapine, methadone, tacrine. Caution with drugs that inhibit CYP2D6 (eg, quinidine) or 3A4, phenytoin, diltiazem. Caution with aspirin, NSAIDs, warfarin, other anticoagulants (increased risk of bleeding). Monitor mexiletine levels. Smokers may have increased metabolism. |
| Adverse Reactions |
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Headache, somnolence, insomnia, nervousness, tremor, GI upset, anorexia, dry mouth, abnormal ejaculation, asthenia, sweating, decreased libido, rhinitis, anorgasmia, taste perversion; agitation, irritability, and behavioral changes (monitor). |
| How Supplied |
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Caps—30 |
| Additional Resources |
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• Related Prescribing Note |
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