Monograph Details
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Central Nervous System
> Anxiety/OCD
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LEXAPRO |
| Manufacturer |
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Forest Laboratories |
| Legal Classification |
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Rx
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| Pharmacological Class |
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SSRI. |
| Generic Name |
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Escitalopram (as oxalate) (single-isomer citalopram) 5mg, 10mg+, 20mg+; tabs (+scored). |
| Also |
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• LEXAPRO ORAL SOLUTION
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| Indications |
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Generalized anxiety disorder. |
| Children |
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Not recommended. |
| Adults |
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Initially 10mg once daily; may increase to 20mg once daily after 1 week. Elderly or hepatic impairment: 10mg once daily. |
| Contraindications |
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During or within 14 days of MAOIs; do not start an MAOI during or within 14 days of escitalopram. |
| Precautions |
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History of seizures or mania/hypomania. Hepatic or severe renal impairment (CrCl <20mL/min). Altered metabolic or hemodynamic states. Recent MI. Unstable heart disease. Suicidal tendencies. ECT. Avoid abrupt cessation. Reevaluate periodically. Write Rx for smallest practical amount. Labor & delivery. Pregnancy (Cat.C) (avoid 3rd trimester; see literature for effects on neonate). Nursing mothers: not recommended. |
| Interactions |
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MAOIs: see Contraindications. Do not give with citalopram. Alcohol: not recommended. May be antagonized by carbamazepine. Caution with drugs metabolized by CYP2D6, centrally-acting drugs, lithium, oral anticoagulants, NSAIDs, aspirin. Increases metoprolol levels. Weakness, incoordination, hyperreflexia with 5-HT1B/1D agonists (eg, sumatriptan). |
| Adverse Reactions |
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Nausea, insomnia, somnolence, ejaculation disorder, fatigue, increased sweating, sexual dysfunction, decreased libido, anorgasmia, decreased appetite, abnormal bleeding, dizziness; others. |
| How Supplied |
Tabs—100
Soln—240mL |
| Additional Resources |
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• Related Prescribing Note |
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