Monograph Details
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Central Nervous System
> Anxiety/OCD
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BUSPAR |
| Manufacturer |
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Bristol-Myers Squibb |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Azaspirone. |
| Generic Name |
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Buspirone HCl 5 mg, 10 mg, 15 mg+, 30 mg+; scored (+bi/trisected) tabs. |
| Indications |
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Anxiety. |
| Children |
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<6 years: not recommended. 6–17 years: doses of 7.5–30 mg twice daily have been used. |
| Adults |
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Take consistently with regard to food. Initially 7.5 mg twice daily, may increase by 5 mg/day every 2–3 days. Usual range: 20–30 mg/day; max 60 mg/day. |
| Contraindications |
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Concomitant MAOIs. |
| Precautions |
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Severe renal or hepatic impairment: not recommended. Elderly. Labor & delivery. Pregnancy (Cat.B). Nursing mothers: not recommended. |
| Interactions |
Hypertensive crisis with MAOIs: see Contraindications. Avoid alcohol, large amounts of grapefruit juice. Caution with other CNS drugs. May potentiate haloperidol, diazepam, nefazodone.
Potentiated by nefazodone, verapamil, diltiazem, erythromycin, itraconazole, ketoconazole, ritonavir, other CYP3A4 inhibitors (use lower initial dose). Antagonized by rifampin, dexamethasone, phenytoin, phenobarbital, carbamazepine, other CYP3A4 inducers. |
| Adverse Reactions |
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Dizziness, GI upset, headache, nervousness, CNS or emotional effects, nonspecific chest pain, tinnitus, dream disturbances. |
| How Supplied |
Tabs 5 mg, 10 mg—100, 500
15 mg—60, 180
30 mg—60 |
| Additional Resources |
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• Related Prescribing Note |
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