Monograph Details
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Central Nervous System
> Anxiety/OCD
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ANAFRANIL |
| Manufacturer |
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Mallinckrodt, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Tricyclic. |
| Generic Name |
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Clomipramine HCl 25mg, 50mg, 75mg; caps. |
| Indications |
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Obsessive-compulsive disorder. |
| Children |
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<10 yrs: not recommended. Others: initially with food 25mg/day. Increase gradually over first 2 wks to 3mg/kg per day or 100mg/day (in divided doses) whichever is smaller. Further increases as needed to 3mg/kg per day or 200mg/day whichever is smaller. After titration, total daily dose may be given at bedtime. |
| Adults |
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Take with food. Initially 25mg/day; titrate to 100mg/day in divided doses in first 2 weeks. Adjust as needed; max 250mg/day. May give total daily maintenance dose at bedtime. |
| Contraindications |
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During or within 14 days of MAOIs. Acute post-MI. |
| Precautions |
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Glaucoma. Adrenal tumors. Urinary retention. Suicidal tendencies. Cardiovascular disease. Epilepsy or other seizure risk. Psychosis. Mania/hypomania. Bipolar disorder. Hepatic or renal dysfunction. Hyperthyroidism. ECT. Surgery. Avoid abrupt cessation. Reevaluate periodically. Write Rx for smallest practical amount. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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See Contraindications. Hyperpyretic crisis, seizures, coma and death with MAOIs. Potentiates alcohol, other CNS depressants, anticholinergics, sympathomimetics, other protein-bound drugs. Potentiated by CYP2D6 and/or CYP1A2 inhibitors; monitor plasma levels with cimetidine, SSRIs, phenothiazines, type 1C antiarrhythmics (eg, quinidine). Antagonized by barbiturates, carbamazepine, phenytoin, other CYP450 inducers. Caution with drugs that lower seizure threshold. Blocks guanethidine, clonidine. |
| Adverse Reactions |
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Seizures, male sexual dysfunction, hyperthermia, anticholinergic effects, nausea, dyspepsia, anorexia, somnolence, dizziness, nervousness, changed libido, weight gain, visual changes, blood dyscrasias, neuropsychiatric disturbances. |
| How Supplied |
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Caps—100 |
| Additional Resources |
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• Related Prescribing Note |
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