Monograph Details
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Central Nervous System
> Anxiety/OCD
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Alprazolam INTENSOL |
| Manufacturer |
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Roxane Laboratories, Inc. |
| Legal Classification |
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CIV |
| Pharmacological Class |
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Benzodiazepine. |
| Generic Name |
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Alprazolam 1mg; per 1mL; concentrated soln. |
| Indications |
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Anxiety. |
| Children |
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<18yrs: not recommended. |
| Adults |
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Mix with liquid or semi-solid food. Adjust at intervals of at least 3–4 days. ≥18yrs: initially 0.25–0.5mg 3 times daily; max 4mg daily in divided doses. Elderly, debilitated, or advanced liver disease: initially 0.25mg 2–3 times daily. |
| Contraindications |
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Acute narrow angle glaucoma. Concomitant itraconazole, ketoconazole. |
| Precautions |
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Not for use in untreated open-angle glaucoma. Reevaluate periodically. Change dose gradually. Withdrawal symptoms on abrupt cessation or dose reduction. Suicidal ideation. Psychosis. Mania. Renal, cardiovascular, hepatic, pulmonary dysfunction (monitor). Obesity. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.D), nursing mothers: not recommended. |
| Interactions |
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See Contraindications; other azole antifungals: not recommended. Potentiates CNS depression with alcohol, psychotropics, anticonvulsants, other CNS depressants. Potentiated by CYP3A inhibitors; reduce alprazolam dose; caution with cimetidine, nefazodone, fluvoxamine; caution with weaker CYP3A inhibitors (eg, fluoxetine, propoxyphene, oral contraceptives). Antagonized by CYP3A inducers (eg, carbamazepine). May increase levels of imipramine, desipramine. |
| Adverse Reactions |
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CNS depression; impaired memory, coordination, or attention; dysarthria, ataxia, arthralgia, dyspnea, paradoxical excitement, increased salivation, withdrawal seizures, tremors, decreased libido, sexual dysfunction. |
| How Supplied |
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Soln—30mL (w. dropper) |
| Additional Resources |
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• Related Prescribing Note |
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