Monograph Details
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Central Nervous System
> Alzheimer's dementia
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RAZADYNE |
| Manufacturer |
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Ortho-McNeil Neurologics, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Reversible acetylcholinesterase inhibitor (benzazepine deriv). |
| Generic Name |
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Galantamine (as HBr) 4mg, 8mg, 12mg; tabs. |
| Also |
• RAZADYNE ER
• RAZADYNE ORAL SOLUTION
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| Indications |
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Mild to moderate Alzheimer's dementia. |
| Children |
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Not recommended. |
| Adults |
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Give with AM & PM meals. Initially 4mg twice daily; if well-tolerated may increase by 4mg twice daily at intervals of ≥4 weeks; max 12mg twice daily (24mg/day). Re-titrate if interrupted for more than several days. Moderate hepatic or renal impairment: usual max 16mg/day. |
| Precautions |
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Conduction disorders (eg, AV block). Monitor for GI bleed. History of ulcer. Bladder outflow obstruction. Asthma. COPD. Seizures. Maintain adequate hydration. Severe hepatic or renal impairment (CrCl <9 mL/min): not recommended. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Potentiates neuromuscular blockers (eg, succinylcholine), cholinesterase inhibitors, cholinergic agonists (eg, bethanechol). Antagonizes anticholinergics. Caution with drugs that slow heart rate. May be potentiated by ketoconazole, cimetidine, paroxetine, fluoxetine, erythromycin, possibly others that affect CYP2D6 or CYP3A4. Monitor for GI bleed with NSAIDs. |
| Adverse Reactions |
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GI upset, anorexia, weight loss, syncope, bradycardia. |
| Extra Text |
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Note: This product was formerly named Reminyl. |
| How Supplied |
Tabs—60
Soln—100mL (w. cal. pipette)
ER caps—30 |
| Additional Resources |
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• Related Prescribing Note |
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