Monograph Details
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Central Nervous System
> Alzheimer's dementia
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NAMENDA ORAL SOLUTION |
| Manufacturer |
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Forest Laboratories |
| Legal Classification |
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Rx
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| Pharmacological Class |
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N-methyl-D-aspartate (NMDA) receptor antagonist. |
| Generic Name |
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Memantine HCl 2mg/mL; sugar-and alcohol-free; peppermint flavor. |
| Also |
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• NAMENDA
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| Indications |
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Moderate to severe dementia of the Alzheimer's type. |
| Children |
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Not recommended. |
| Adults |
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Initially 5mg once daily; titrate at intervals of at least 1 week to 5mg twice daily, then to 5mg and 10mg as separate doses, then to 10mg twice daily (prescribe Titration Pak for 1st 4 weeks). Severe renal impairment (CrCl 5–29mL/min): titrate to max 5mg twice daily. |
| Precautions |
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Alkalinized urine (eg, renal tubular acidosis, severe UTI) increases memantine serum levels. Seizure disorder. Pregnancy (Cat.B). Nursing mothers. |
| Interactions |
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Caution with other NMDA antagonists (eg, amantadine, ketamine, dextromethorphan, felbamate). May affect or be affected by renally-excreted drugs (eg, triamterene, HCTZ, cimetidine, nicotine, ranitidine, quinidine). Plasma levels may be increased by urinary alkalinizers. |
| Adverse Reactions |
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Dizziness, headache, constipation, hypertension, pain, GI upset, somnolence, hallucination, dyspnea. |
| How Supplied |
Tabs—60
Titration Pak (28 x 5mg + 21 x 10mg)—1
Oral soln—360mL |
| Additional Resources |
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• Related Prescribing Note |
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