Monograph Details
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Central Nervous System
> Alzheimer's dementia
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ARICEPT |
| Manufacturer |
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Eisai Pharmaceuticals |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Reversible acetylcholinesterase inhibitor (piperidine deriv). |
| Generic Name |
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Donepezil HCl 5mg, 10mg; tabs. |
| Also |
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• ARICEPT ODT
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| Indications |
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Alzheimer's dementia. |
| Children |
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Not applicable. |
| Adults |
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Mild-moderate: Initially 5mg daily at bedtime. Severe: 10mg daily at bedtime. All: may increase to 10mg daily after 5mg dose given for 4–6 weeks. ODT: dissolve on tongue, then drink water. |
| Precautions |
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Cardiac conduction conditions. Monitor for GI bleeding. Seizures. Asthma. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Drugs that affect CYP2D6 and CYP3A4 may affect rate of elimination. Antagonizes anticholinergics. May potentiate succinylcholine-type muscle relaxants, other cholinesterase inhibitors, cholinergic agonists (eg, bethanecol). Concomitant NSAIDs may increase risk of GI bleed. |
| Adverse Reactions |
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GI upset, insomnia, muscle cramps, fatigue, anorexia. |
| How Supplied |
Tabs—30, 90
ODT—30 |
| Additional Resources |
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• Related Prescribing Note |
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