Monograph Details
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Central Nervous System
> ADHD/narcolepsy
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METHYLIN ORAL SOLUTION |
| Manufacturer |
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Alliant Pharmaceuticals, Inc. |
| Legal Classification |
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CII |
| Pharmacological Class |
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Stimulant. |
| Generic Name |
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Methylphenidate HCl 5mg/5mL, 10mg/5mL; grape flavor. |
| Also |
• METHYLIN
• METHYLIN CHEWABLE
• METHYLIN ER
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| Indications |
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Attention deficit hyperactivity disorder. Narcolepsy. |
| Children |
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<6yrs: not recommended. ≥6yrs: initially 5mg twice a day before breakfast and lunch. Increase gradually by 5–10mg per week if needed; max 60mg daily. |
| Adults |
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10–60mg daily in 2–3 divided doses preferably 30–45 minutes before meals. |
| Contraindications |
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During or within 14 days of MAOIs. Marked anxiety, tension, agitation. Glaucoma. History of tics or Tourette's syndrome in patient or family. |
| Precautions |
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Discontinue if seizures or agitation occur. Reduce dose or discontinue if paradoxical excitement occurs. Reassess periodically. Reevaluate therapy at puberty. Hypertension. Psychosis. Seizure disorders. Depression. Normal fatigue states. Emotionally unstable (e.g., drug or alcohol abusers). Abuse potential. May exacerbate behavior disturbances, thought disorders. Monitor growth, blood pressure, CBC, differential, and platelet counts. Pregnancy or women of childbearing potential: not recommended. |
| Interactions |
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See Contraindications. Caution with pressor agents, anticonvulsants, α2-agonists (eg, clonidine). May increase levels of anticonvulsants, oral anticoagulants, tricyclics, phenylbutazone. Antagonizes guanethidine, other antihypertensives. |
| Adverse Reactions |
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Insomnia, nervousness, CNS overstimulation, anorexia, weight loss, abdominal pain, nausea, dizziness, headache, dyskinesias, hypertension, tachycardia, arrhythmias, Tourette's syndrome, toxic psychosis, seizures, blood dyscrasias, rash, visual disturbances. |
| How Supplied |
Tabs—100, 1000
Chews tabs—100
Oral soln—500mL
ER—100 |
| Additional Resources |
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• Related Prescribing Note |
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