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Central Nervous System > ADHD/narcolepsy

METADATE CD

Manufacturer

UCB Inc.

Legal Classification

CII

Pharmacological Class

Stimulant.

Generic Name

Methylphenidate HCl 10mg, 20mg, 30mg, 40mg, 50mg, 60mg; ext-rel caps (contains immediate-release + ext-rel beads).

Also

• METADATE ER

Indications

Attention deficit hyperactivity disorder.

Adults and Children

Take before breakfast. Swallow whole or sprinkle contents onto applesauce (swallow immediately); do not crush, chew, or divide beads. <6 years: not recommended. ≥6 years: initially 20mg once daily, may increase weekly by 10–20mg/day; max 60mg once daily.

Contraindications

During or within 14 days of MAOIs. Marked anxiety, tension, agitation. Severe depression. Psychosis. History of aggression. Suicidal tendency. Severe hypertension. Angina. Cardiac arrhythmias. Heart failure. Recent MI. Hyperthyroidism. Thyrotoxicosis. Glaucoma. History of tics or Tourette's syndrome in patient or family.

Precautions

Discontinue if seizures or agitation occur. Reduce dose or discontinue if paradoxical worsening of symptoms occurs. Reassess periodically. Reevaluate therapy at puberty. Hypertension. Seizure disorders. Normal fatigue states. Emotionally unstable (eg, drug or alcohol abusers). Abuse potential. May exacerbate behavior disturbances, thought disorders. Monitor growth, BP, CBC, differential, and platelet counts. Interrupt therapy if growth suppression occurs. Structural cardiac abnormalities: see literature. Pregnancy (Cat.C). Nursing mothers.

Interactions

See Contraindications. Caution with pressor agents, α₂-agonists (eg, clonidine). May increase levels of anticonvulsants, oral anticoagulants, tricyclics, SSRIs, phenylbutazone. Antagonizes guanethidine.

Adverse Reactions

Headache, anorexia, abdominal pain, insomnia, nervousness, CNS overstimulation, weight loss, nausea, dizziness, dyskinesias, hypertension, tachycardia, arrhythmias, Tourette's syndrome, toxic psychosis, seizures, blood dyscrasias, rash, visual disturbances.

How Supplied

CD—100
ER—100

Additional Resources

• Related Prescribing Note