Monograph Details
|
|
Central Nervous System
> ADHD/narcolepsy
|
|
DEXEDRINE SPANSULE |
| Manufacturer |
|
GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
|
CII |
| Pharmacological Class |
|
Amphetamine. |
| Generic Name |
|
Dextroamphetamine sulfate 5mg, 10mg, 15mg; sust rel caps. |
| Also |
|
• DEXEDRINE
|
| Indications |
|
Attention deficit hyperactivity disorder. Narcolepsy. |
| Children |
|
Avoid late evening dosing; give tabs on awakening and 4–6 hrs apart; may switch to once-daily dosing with spansules when titrated. <3yrs: not recommended. ADHD: 3–5yrs: initially 2.5mg daily; may increase by 2.5mg/day at weekly intervals. ≥6yrs: initially 5mg 1–2 times daily; may increase by 5mg/day at weekly intervals; usual max 40mg/day. Narcolepsy: 6–12yrs: initially 5mg daily; may increase by 5mg/day at weekly intervals. >12yrs: initially 10mg daily; may increase by 10mg/day at weekly intervals. |
| Adults |
|
Avoid late evening dosing; give tabs on awakening and 4–6 hrs apart; may switch to once-daily dosing with spansules when titrated. Narcolepsy: 5–60mg daily in divided doses. |
| Contraindications |
|
Cardiovascular disease. Hypertension. Arteriosclerosis. Hyperthyroidism. Glaucoma. Drug or alcohol abuse. Agitation. During or within 14 days of MAOIs. Hypersensitivity to sympathomimetics. |
| Precautions |
|
Structural cardiac abnormalities: see literature. Tourette's syndrome. Psychosis. Bipolar disorder. Aspirin sensitivity. Monitor growth. Abuse potential. Prescribe limited supply to minimize overdose. Reevaluate need for therapy after drug-free interval. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
|
Potentiated with alkalinizers, MAOIs, tricyclic antidepressants, propoxyphene. Potentiates meperidine, norepinephrine, phenobarbital, phenytoin. Antagonized with acidifiers, psychotropics, lithium. Inhibits effects of adrenergic blockers, ethosuximide. |
| Adverse Reactions |
|
Hypertension, tachycardia, CNS overstimulation, dry mouth, GI disorders, anorexia, urticaria, visual disturbances. |
| How Supplied |
Tabs—100
Caps 5mg—90, 100
10mg, 15mg—90 |
| Additional Resources |
|
• Related Prescribing Note |
|
|
|
|
