Monograph Details
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Central Nervous System
> ADHD/narcolepsy
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DEXEDRINE |
| Manufacturer |
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GlaxoSmithKline Pharmaceuticals |
| Legal Classification |
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CII |
| Pharmacological Class |
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Amphetamine. |
| Generic Name |
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Dextroamphetamine sulfate 5mg; scored tabs; contains tartrazine. |
| Also |
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• DEXEDRINE SPANSULE
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| Indications |
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Attention deficit hyperactivity disorder. Narcolepsy. |
| Children |
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Avoid late evening dosing; give tabs on awakening and 4–6 hrs apart; may switch to once-daily dosing with spansules when titrated. <3yrs: not recommended. ADHD: 3–5yrs: initially 2.5mg daily; may increase by 2.5mg/day at weekly intervals. ≥6yrs: initially 5mg 1–2 times daily; may increase by 5mg/day at weekly intervals; usual max 40mg/day. Narcolepsy: 6–12yrs: initially 5mg daily; may increase by 5mg/day at weekly intervals. >12yrs: initially 10mg daily; may increase by 10mg/day at weekly intervals. |
| Adults |
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Avoid late evening dosing; give tabs on awakening and 4–6 hrs apart; may switch to once-daily dosing with spansules when titrated. Narcolepsy: 5–60mg daily in divided doses. |
| Contraindications |
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Cardiovascular disease. Hypertension. Arteriosclerosis. Hyperthyroidism. Glaucoma. Drug or alcohol abuse. Agitation. During or within 14 days of MAOIs. Hypersensitivity to sympathomimetics. |
| Precautions |
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Structural cardiac abnormalities: see literature. Tourette's syndrome. Psychosis. Bipolar disorder. Aspirin sensitivity. Monitor growth. Abuse potential. Prescribe limited supply to minimize overdose. Reevaluate need for therapy after drug-free interval. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Potentiated with alkalinizers, MAOIs, tricyclic antidepressants, propoxyphene. Potentiates meperidine, norepinephrine, phenobarbital, phenytoin. Antagonized with acidifiers, psychotropics, lithium. Inhibits effects of adrenergic blockers, ethosuximide. |
| Adverse Reactions |
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Hypertension, tachycardia, CNS overstimulation, dry mouth, GI disorders, anorexia, urticaria, visual disturbances. |
| How Supplied |
Tabs—100
Caps 5mg—90, 100
10mg, 15mg—90 |
| Additional Resources |
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• Related Prescribing Note |
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