Monograph Details
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Central Nervous System
> ADHD/narcolepsy
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CONCERTA |
| Manufacturer |
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McNeil Pediatrics |
| Legal Classification |
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CII |
| Pharmacological Class |
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Stimulant. |
| Generic Name |
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Methylphenidate HCl 18mg, 27mg, 36mg, 54mg; ext-rel tabs. |
| Indications |
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Attention deficit hyperactivity disorder. |
| Adults and Children |
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Swallow whole with liquids. Take once daily in the AM. <6years: not recommended. Methylphenidate-naive: 6–12years: initially 18mg once daily, max 54mg/day; 13–17years: initially 18mg once daily, max 72mg daily or 2mg/kg per day (whichever is less). 18–65years: initially 18mg or 36mg/day; max 72mg/day. Switching from methylphenidate 5mg 2 or 3 times daily: initially Concerta 18mg once daily. Switching from methylphenidate 10mg 2 or 3 times daily: initially Concerta 36mg once daily. Switching from methylphenidate 15mg 2 or 3 times daily: initially Concerta 54mg once daily. Switching from methylphenidate 20mg 2 or 3 times daily: initially Concerta 72mg once daily. For all: may adjust in 18mg/day increments at 1-week intervals; max 54mg/day for children; max 72mg/day for adolescents and adults. |
| Contraindications |
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Marked anxiety, tension, agitation. Glaucoma. Motor tics. Tourette's syndrome in patient or family. During or within 14 days of MAOIs. |
| Precautions |
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Discontinue if seizures occur. Structural cardiac abnormalities, cardiomyopathy, serious heart rhythm abnormalities, coronary artery disease: not recommended. Hypertension. Heart failure. Recent MI. Reduce dose or discontinue if paradoxical worsening of symptoms occurs. Reevaluate periodically. GI narrowing. Hyperthyroidism. Psychosis. Bipolar disorder. Seizure disorders. Depression. Normal fatigue states. Emotionally unstable (eg, drug or alcohol abusers). May exacerbate behavior disturbances, thought disorders; monitor for worsening aggressive behavior or hostility. Monitor growth, blood pressure, CBC, differential, platelet counts. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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See Contraindications. Hypertensive crisis with MAOIs. Caution with pressor agents, central α2-agonists (eg, clonidine). May increase levels of anticonvulsants, coumarin anticoagulants, tricyclics, SSRIs (eg, fluoxetine). |
| Adverse Reactions |
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Decreased appetite, headache, dry mouth, nausea, insomnia, anxiety, dizziness, weight loss, irritability, hyperhidrosis, hypertension, visual disturbances. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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