Monograph Details
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Central Nervous System
> ADHD/narcolepsy
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ADDERALL XR |
| Manufacturer |
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Shire US, Inc. |
| Legal Classification |
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CII |
| Pharmacological Class |
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Amphetamine. |
| Generic Name |
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Mixed salts of a single-entity amphetamine product (each cap contains equal parts dextroamphetamine saccharate, dextroamphetamine sulfate, amphetamine aspartate, amphetamine sulfate); 5mg, 10mg, 15mg, 20mg, 25mg, 30mg; ext-rel caps. |
| Also |
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• ADDERALL
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| Indications |
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Attention deficit hyperactivity disorder. |
| Adults and Children |
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Swallow whole or may sprinkle contents of caps on applesauce; do not chew beads. <6years: not recommended. 6–12years: initially 5–10mg once daily in the AM, may increase by 5–10mg/day at weekly intervals; max 30mg/day. 13–17years: initially 10mg once daily in the AM; may increase to 20mg/day after 1 week. >17years: 20mg once daily in the AM. Switching from Adderall immediate-release: give total daily dose of immediate-release once daily in the AM. |
| Contraindications |
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Advanced arteriosclerosis. Cardiovascular disease. Moderate to severe hypertension. Hyperthyroidism. Glaucoma. Drug or alcohol abuse. Agitation. During or within 14 days of MAOIs. Hypersensitivity to sympathomimetics. Structural heart defects. |
| Precautions |
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Tourette's syndrome. Psychosis. Hypertension. Seizure disorders. Monitor growth in children. Reevaluate periodically. Write Rx for smallest practical amount. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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See Contraindications. Potentiated by alkalinizers (eg, thiazides), tricyclic antidepressants, propoxyphene. Potentiates meperidine, norepinephrine, phenobarbital, phenytoin, tricyclic antidepressants. Antagonized by acidifiers, psychotropics, lithium. Antagonizes adrenergic blockers, sedatives, antihypertensives. Monitor phenytoin, ethosuximide, phenobarbital. Convulsions with propoxyphene overdose and amphetamines. May interfere with urinary steroid tests. |
| Adverse Reactions |
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Anorexia, insomnia, GI upset, emotional lability, nervousness, fever, dizziness, hypertension, tachycardia, dry mouth, psychosis, tics, headache; adults: also UTI. |
| How Supplied |
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All—100 |
| Additional Resources |
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• Related Prescribing Note |
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