Monograph Details
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Central Nervous System
> ADHD/narcolepsy
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ADDERALL |
| Manufacturer |
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Shire US, Inc. |
| Legal Classification |
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CII |
| Pharmacological Class |
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Amphetamine. |
| Generic Name |
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Mixed salts of a single-entity amphetamine product (each tab contains equal parts dextroamphetamine saccharate, dextroamphetamine sulfate, amphetamine aspartate, amphetamine sulfate); 5mg, 7.5mg, 10mg, 12.5mg, 15mg, 20mg, 30mg; double-scored tabs. |
| Also |
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• ADDERALL XR
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| Indications |
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Attention deficit disorder. Narcolepsy. |
| Adults and Children |
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Avoid late evening doses; give upon awakening and 4–6 hours apart. ADHD: <3years: not recommended. 3–5years: initially 2.5mg once daily, may increase by 2.5mg weekly. ≥6years: initially 5mg 1–2 times daily, may increase by 5mg weekly; usual max 40mg/day in 2–3 divided doses. Narcolepsy: <12years: use dextroamphetamine sulfate; ≥12years: usual range 5–60mg/day in divided doses. |
| Contraindications |
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Advanced arteriosclerosis. Cardiovascular disease. Moderate to severe hypertension. Hyperthyroidism. Glaucoma. Drug or alcohol abuse. Agitation. During or within 14 days of MAOIs. Hypersensitivity to sympathomimetics. Structural heart defects. |
| Precautions |
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Tourette's syndrome. Psychosis. Hypertension. Seizure disorders. Monitor growth in children. Reevaluate periodically. Write Rx for smallest practical amount. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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See Contraindications. Potentiated by alkalinizers (eg, thiazides), tricyclic antidepressants, propoxyphene. Potentiates meperidine, norepinephrine, phenobarbital, phenytoin, tricyclic antidepressants. Antagonized by acidifiers, psychotropics, lithium. Antagonizes adrenergic blockers, sedatives, antihypertensives. Monitor phenytoin, ethosuximide, phenobarbital. Convulsions with propoxyphene overdose and amphetamines. May interfere with urinary steroid tests. |
| Adverse Reactions |
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Anorexia, insomnia, GI upset, emotional lability, nervousness, fever, dizziness, hypertension, tachycardia, dry mouth, psychosis, tics, headache; adults: also UTI. |
| How Supplied |
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All—100 |
| Additional Resources |
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• Related Prescribing Note |
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