Monograph Details
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Cardiovascular System
> Pulmonary hypertension
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VENTAVIS |
| Manufacturer |
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CoTherix, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Prostacyclin analogue. |
| Generic Name |
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Iloprost 10micrograms/mL; soln for inhalation using I-neb or Prodose AAD System; preservative-free. |
| Indications |
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Pulmonary arterial hypertension (WHO Group I) in patients with NYHA Class III or IV symptoms. |
| Children |
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Not recommended. |
| Adults |
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Initially 2.5micrograms then 5micrograms 6–9 times daily based on tolerability (no more than every 2 hrs); max 45micrograms/day. |
| Precautions |
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Do not start therapy if systolic BP <85 mmHg. Discontinue immediately if pulmonary edema occurs (may indicate pulmonary venous hypertension). Bleeding disorders. Avoid contact with eyes and skin, oral ingestion. COPD. Severe asthma. Acute pulmonary infections. Hepatic or renal impairment. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Potentiates hypotensive effect of vasodilators and antihypertensives. May potentiate anticoagulants. |
| Adverse Reactions |
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Vasodilation, increased cough, headache, lockjaw, insomnia, GI upset, hypotension, flu syndrome, back pain, abnormal lab tests (eg, increased GGT, alkaline phosphatase), tongue pain, palpitations, syncope, muscle cramps, hemoptysis, pneumonia, CHF, chest pain, supraventricular tachycardia, dyspnea, peripheral edema, kidney failure. |
| How Supplied |
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Single-use ampule (20microgram/2mL)—30, 100 |
| Additional Resources |
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• Related Prescribing Note |
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