Monograph Details
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Cardiovascular System
> Hypotension
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PROAMATINE |
| Manufacturer |
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Shire US, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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α1-agonist. |
| Generic Name |
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Midodrine HCl 2.5mg, 5mg, 10mg; scored tabs. |
| Indications |
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Symptomatic orthostatic hypotension. |
| Children |
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Not recommended. |
| Adults |
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Take during the day while upright; allow at least 4 hours between last dose and bedtime. 10mg 3 times daily at 3–4 hour intervals. Renal dysfunction: initially 2.5mg 3 times daily. Discontinue if no improvement after initial therapy. |
| Contraindications |
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Severe heart disease. Acute renal disease. Urinary retention. Pheochromocytoma. Thyrotoxicosis. Persistent, excessive supine hypertension. Initial supine systolic pressure >180 mmHg: not recommended. |
| Precautions |
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Monitor supine and sitting BP. Discontinue if supine hypertension occurs. Diabetes. Renal or hepatic impairment. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Potentiated by α-agonists (eg, pseudoephedrine, ergots) and sodium-retaining steroids (eg, fludrocortisone); caution in increased intraocular pressure with fludrocortisone. Antagonized by α-antagonists (eg, prazosin). Levels may be affected by renally-excreted alkaline drugs (eg, metformin, cimetidine, ranitidine, procainamide, triamterene, flecainide, quinidine). Cardiac glycosides, β-blockers, CNS drugs may cause bradycardia, AV block, arrhythmias; discontinue if bradycardia occurs. |
| Adverse Reactions |
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Paresthesia, piloerection, dysuria, pruritus, supine hypertension, chills, pain, rash. |
| How Supplied |
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Tabs—100 |
| Additional Resources |
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• Related Prescribing Note |
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