Monograph Details
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Cardiovascular System
> Hypertension
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ZEBETA |
| Manufacturer |
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Duramed Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Cardioselective β-blocker. |
| Generic Name |
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Bisoprolol (as fumarate) 5mg+, 10mg; tabs; +scored. |
| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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5mg once daily; max 20mg once daily. Renal or hepatic dysfunction, or bronchospastic disease: initially 2.5mg once daily. |
| Contraindications |
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Cardiogenic shock. Overt heart failure. 2nd- or 3rd-degree AV block. Marked sinus bradycardia. |
| Precautions |
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CHF. Angina. Peripheral vascular disease. Asthma. COPD. Surgery. Diabetes. Thyroid disease. Hepatic or renal impairment. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers. |
| Interactions |
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Additive effects with reserpine, guanethidine, other catecholamine depleting drugs, calcium channel blockers, antiarrhythmics, myocardial depressants. Increased rebound hypertension with clonidine withdrawal. Antagonized by rifampin. May block epinephrine. |
| Adverse Reactions |
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Headache, fatigue, GI upset, upper respiratory symptoms (eg, cough, dyspnea, rhinitis), chest pain. |
| How Supplied |
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Tabs—30 |
| Additional Resources |
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• Related Prescribing Note |
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