Monograph Details
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Cardiovascular System
> Hypertension
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VERELAN PM |
| Manufacturer |
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Schwarz Pharma, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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Calcium channel blocker (diphenylalkylamine). |
| Generic Name |
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Verapamil HCl 100mg, 200mg, 300mg; controlled-onset ext-rel caps. |
| Also |
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• VERELAN
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| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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Give once daily at bedtime. May sprinkle contents on applesauce; do not crush or chew contents. Initially 200mg; may titrate upwards in steps to 300mg, then 400mg if necessary. May start at 100mg in impaired renal or hepatic function, elderly or small patients. |
| Contraindications |
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Severe left ventricular (LV) dysfunction or LV dysfunction treated with β-blockers. Moderate to severe heart failure. Hypotension. Cardiogenic shock. Sick sinus syndrome, 2nd- or 3rd-degree AV block, unless paced. Atrial flutter or fibrillation and an accessory bypass tract. |
| Precautions |
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Control mild heart failure (eg, with digitalis, diuretics). AV conduction or neuromuscular transmission disorders. Hepatic or renal dysfunction. Monitor liver function. Hypertrophic cardiomyopathy. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Potentiates alcohol, α- and β-blockers, other antihypertensives, digitalis, theophylline, neuromuscular blockers, flecainide, carbamazepine, cyclosporine. Potentiated by grapefruit juice. Avoid disopyramide; quinidine in cardiomyopathy. Potentiated by CYP3A4 inhibitors (eg, erythromycin, ritonavir); antagonized by CYP3A4 inducers (eg, rifampin). Inhalation anesthetics may potentiate cardiac depression. May increase bleeding with aspirin. Monitor theophylline, lithium, cyclosporine. |
| Adverse Reactions |
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Hypotension, edema, AV block, bradycardia, CHF, constipation, headache, dizziness, fatigue, dyspepsia, elevated hepatic enzymes, paralytic ileus. |
| How Supplied |
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Caps—100 |
| Additional Resources |
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• Related Prescribing Note |
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