Monograph Details
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Cardiovascular System
> Hypertension
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VERELAN |
| Manufacturer |
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Schwarz Pharma, Inc. |
| Legal Classification |
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Rx
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| Generic Name |
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Verapamil HCl 120mg, 180mg, 240mg, 360mg; sust-rel caps. |
| Also |
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• VERELAN PM
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| Indications |
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Hypertension. |
| Children |
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<18yrs: not recommended. |
| Adults |
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Take as a single dose in the AM. May sprinkle contents on applesauce; do not crush or chew contents. Over 18 yrs: usually 240mg daily; adjust in 120mg increments. Elderly, small people, others with increased sensitivity: 120mg daily; if needed, may increase daily dose to 180mg, then 240mg, then higher in 120mg increments; max 480mg daily. |
| Contraindications |
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Severe left ventricular (LV) dysfunction or LV dysfunction treated with β-blockers. Moderate to severe heart failure. Hypotension. Cardiogenic shock. Sick sinus syndrome, 2nd- or 3rd-degree AV block, unless paced. Atrial flutter or fibrillation and an accessory bypass tract. |
| Precautions |
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Control mild heart failure (eg, with digitalis, diuretics). AV conduction or neuromuscular transmission disorders. Hepatic or renal dysfunction. Monitor liver function. Hypertrophic cardiomyopathy. Pregnancy (Cat.C). Nursing mothers: not recommended. |
| Interactions |
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Potentiates alcohol, α- and β-blockers, other antihypertensives, digitalis, theophylline, neuromuscular blockers, flecainide, carbamazepine, cyclosporine. Potentiated by grapefruit juice. Avoid disopyramide; quinidine in cardiomyopathy. Potentiated by CYP3A4 inhibitors (eg, erythromycin, ritonavir); antagonized by CYP3A4 inducers (eg, rifampin). Inhalation anesthetics may potentiate cardiac depression. May increase bleeding with aspirin. Monitor theophylline, lithium, cyclosporine. |
| Adverse Reactions |
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Hypotension, edema, AV block, bradycardia, CHF, constipation, headache, dizziness, fatigue, dyspepsia, elevated hepatic enzymes, paralytic ileus. |
| How Supplied |
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Caps—100 |
| Additional Resources |
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• Related Prescribing Note |
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