Monograph Details
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Cardiovascular System
> Hypertension
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VASOTEC |
| Manufacturer |
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Biovail Pharmaceuticals, Inc. |
| Legal Classification |
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Rx
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| Pharmacological Class |
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ACE inhibitor. |
| Generic Name |
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Enalapril maleate 2.5mg+, 5mg+, 10mg, 20mg; tabs; +scored. |
| Indications |
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Hypertension. |
| Children |
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Not recommended. |
| Adults |
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If on diuretics or CrCl <30mL/min: suspend diuretic for 2–3 days, if possible: initially 2.5mg daily; max 40mg. Monitor closely for first 2 wks. Others: initially 5mg daily. Usual range: 10–40mg daily in 1–2 divided doses. |
| Contraindications |
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History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2nd and 3rd trimesters). |
| Precautions |
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Renal impairment. Salt/volume depletion. CHF. Dialysis (esp. high-flux membrane). Renal artery stenosis. Surgery. Monitor for hyperkalemia in diabetics. Monitor WBCs in renal or collagen vascular disease. Discontinue if neutropenia, angioedema, or laryngeal edema occurs. Pregnancy (Cat.C in 1st trimester). Nursing mothers. |
| Interactions |
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Hypotension with diuretics. Hyperkalemia with K+-sparing diuretics or K+ supplements. May increase lithium levels. |
| Adverse Reactions |
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Cough, headache, dizziness, fatigue, diarrhea, rash, orthostatic hypotension, asthenia, hyperkalemia, renal impairment, nausea. |
| How Supplied |
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Tabs—90, 100, 1000 |
| Additional Resources |
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• Related Prescribing Note |
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